Maty's Organic Children's Mucus Cough Syrup, Made with Organic Honey, Thyme & Ginger - 6 fl oz. In principle, antitussives for the treatment of cough as a symptom of an acute bronchitis should have a good tolerability and low toxicity, especially when intended to be used in children. Cough syrup (Prospan; Panoto-s; Athos; Abrilar) containing English ivy leaf extract is POSSIBLY SAFE when taken by mouth three times daily for 1 week. Hedera helix. One patient reported at the final visit to have “discontinued treatment” after 8 days and switched to ACC due to lack of efficacy. The German College of General Practitioners and Family Physicians (DEGAM) guidance describes the health-economic relevance of acute bronchitis as well [11]. At the beginning, BSS average was 6.5 points in the EA 575® group and 6.7 points in the group of ACC patients, respectively, showing a moderate impairment for both. English ivy leaf extract might cause mild stomach problems.. Not enough is known about the safety of applying English ivy to the skin. Other secondary parameters from patients’ assessment coming from the diary included the coughing intensity, chest pain during coughing, dyspnoea during coughing, cough-related sleep disturbances, and possibility to cough-up mucus resulting in a comparable improvement. Copyright © 2020 Esther Kruttschnitt et al. In addition, the EA 575® preparation showed to be effective in children and adults independent of the indication or concomitant disease and can therefore be used as an alternative to the synthetic ACC preparation. Coughing fits was the most common finding. Two galenical formulations of an ivy herbal extract, syrup and cough drops, were tested for their efficacy and safety in the paediatric treatment of cough and bronchitis in two independent open, non-interventional studies with identical design. Other characteristic symptoms include sputum production, shortness of breath, and wheezing related to the obstruction of the inflamed airways. Over the entire treatment period, there was a reduction to 1.8 points in the EA 575® group and to 2.1 points in the ACC groups corresponding to a low impairment in both groups and showing a comparable continuous improvement in both groups. Open trials to assess aspects of safety and efficacy of a combined herbal cough syrup with Ivy and Thyme. The physician selected the patients for whom the diagnosis enabled them to be included into the study and to be treated with the abovementioned prescriptions. During the study, two unwanted events occurred. Granulate: for 12 years and older and adults, three times daily, one sachet 200 mg, and for children up to 12 years, three times daily, one sachet 100 mg. Effervescent tablet: for 12 years and older and adults, one time daily, one tablet 600 mg. Cough lasting less than 3 weeks is termed acute compared with the chronic bronchitis [11]. Regarding concomitant diseases, 44.1% of the subjects in the EA 575® group suffered from concomitant diseases and 38.1% in the ACC group. Average values of physician’s evaluation comparing the final visit with the entry visit. ACC mono acetylcysteine preparation (granulate, syrup, or effervescent tablet, products available in the Swiss market): The following doses are recommended according to the summary of product characteristics. Prospan syrup Ivy leaf dry extract Read all of this leaflet carefully before you start using this medicine because it contains important information for you. Ivy creepers grow up to 30 meters long with a permanent green leaves and numerous aerial roots which help it affix on trees and stones. Introduction. Herbion Naturals Ivy Leaf Syrup with Thyme and Licorice, 5 fl oz- Helps Maintain Respiratory and Bro… from a wet cough; active substance: ivy leaf extract; syrup; country of production: Ukraine containing ivy leaf extract. - Keep this leaflet. The study was conducted as prospective, open, noninterventional cohort study by ambulant physicians (such as general practitioners, internists, paediatricians, pneumologists, and otorhinolaryngologists) throughout Switzerland. Results of trials with different extracts are only valid for the tested preparation but not for the tested plant [15]. Product: Cofif Plus Syrup. No statistical significance was seen between the treatments. There were no specifications available for the calculation of a reasonable sample size; sample size of 300 patients deemed to be sufficient based on the previous studies and practical reasons. oz. PROSPANEX® Cough Syrup: 5 ml contains 35 mg Hedera helix leaves dry extract (DER 5–7.5 : 1) as active ingredient, manufactured by Engelhard Arzneimittel GmbH and Co. KG. At entry visit, all clinical assessments including coughing fits, sputum, dyspnoea, rales, severity of the diseases, and coughing quality were rated with moderate intensity in both groups. PROSPAN ® Cough Syrup with ivy leaf offers reliable help with the excessive formation of thick mucous and coughs associated with colds.. An exclusive extraction method and absolute precision in production ensure the quality of the dried ivy leaf extract that makes PROSPAN® such an effective and safe remedy. The severity of the disease and the calculated BSS showed the same result (Figure 2). Acute bronchitis affects approximately 5% of adults annually, with a higher incidence observed during winter and fall than in summer and spring [3, 4]. The average age was 44.3 years for the EA 575® group and 49.1 years for the ACC group. Introduction: Ivy leaf extract is an essential oil extracted from plant leaves. oz. Syrup: for children up to 12 years, 5 ml, three times daily, and for 12 years and older and adults, 10 ml, three times daily. Ivy leaf extract is a traditional ingredient that has been used for centuries to support bronchial health. The following clinical findings were documented during both visits by the physicians in accordance with the Bronchitis Severity Score (BSS) [16] by a 5-stage assessment: coughing fits, sputum, rales/rhonchi, and dyspnoea during coughing. The evaluation of the individual data on symptoms was only carried out for those patients in whom the symptom was present at the beginning of the study. EA 575® is effectively independent of the indication or concomitant disease. Results of this multicenter study proved the advantage of the treatment of ivy leaves in acute bronchitis that is evidently comparable with acetylcysteine. Compared with the conventional quality control method that measures the contents of hederacoside C in ivy leaf extracts, the newly developed method can provide more information about the chemical composition of ivy leaf extracts. The present noninterventional study was intended to gain further data on the application of a cough syrup containing ivy leaf extract EA 575® by evaluating its efficacy and safety in children and adults with symptoms of acute bronchitis. ), Clear, Herbion Naturals Ivy Leaf Syrup with Thyme and Licorice, 5 - Helps Maintain Respiratory and Bronchial Health, Supports Healthy Mucous Membranes, Effective for Adults and Children 5 Fl Oz (Pack of 1), Prospan 100mL By Helixia - Ivy Leaf Extract - Relieves Cough, Loosens Mucus & Phlegm, Zarbee's Naturals Baby Cough Syrup + Mucus with Agave & Ivy Leaf, Natural Cherry Flavor, 2 Ounce Bottle, Zarbee's Naturals Children's Cough Syrup* + Mucus Daytime & Nighttime, Grape Flavor, 4 Ounces (Pack of 2), Nature's Way B&T Nighttime Cough & Bronchial Syrup for Restful Sleep Homeopathic, Purple, Cherry 8 Fl Oz, Zarbee's Naturals Children's Cough Syrup* + Mucus with Dark Honey & Ivy Leaf, Cherry Flavor, 4 Ounce Bottle, Helixia Prospan Children's Cough Syrup ages 1 to 11, Children's Robitussin Naturals & Ivy Leaf Cough Relief Gummies, Dietary Supplement, Ages 3+, Honey, 30 Count, Robitussin Naturals Cough Relief Ivy Leaf Gummies 30ct, Robitussin Honey Adult Cough + Chest Congestion DM Maximum Strength Liquid & Robitussin Honey Adult Nighttime Cough DM Maximum Strength Liquid Value Pack (2-4 fl. The data used to support the findings of this study are available from the corresponding author upon request. Viral infection-caused acute bronchitis was the most common disease at entry visit with 53.4% in the EA 575® group and 57.1% in the ACC group, followed by other acute inflammation of the respiratory diseases with 25.4% in the EA 575® group and 33.3% in the ACC group. Acute bronchitis is usually a self-limited condition. It is characterized by a persistent cough which can be productive or dry. Since data were incomplete for this patient, it was not considered in the overall study assessment. Of the 118 patients included in the evaluation with EA 575®, treatment was carried out over an average period of 7.48 days. Patients or their parents rated the tolerability as “very good” and “good” with 98.3% in the EA 575® group and 90.5% for the ACC group. These effects are attributable, in particular, to the therapeutically important constituents of the ivy leaf extract, which belong to the class of triterpene saponins such as hederacoside C (Figure 1), a marker and an active ingredient of ivy leaf extract [7–10]. We are committed to sharing findings related to COVID-19 as quickly as possible. Top subscription boxes – right to your door, © 1996-2020, Amazon.com, Inc. or its affiliates. Extraction solvent: ethanol 30 % w/w. The authors declare that there are no conflicts of interest. The same extract is contained as active ingredient in the present noninterventional study. There were 4 different consent forms used in the study depending on the age of the subjects: one consent form for adult subjects, one form for subjects ranging between 14 and 18 years old (signed by the subjects), one form for subjects between ages 11 and 13 years who can already read the document by themselves (signed by the parents), and one form for parents of subjects between 6 and 11 years (signed by parents). 4.1 out of 5 stars 65. $16.39$16.39 ($3.21/Fl Oz) FREE Shipping. The study results indicate that ivy leaf extract might be an effective alternative to acetylcysteine with respect to the improvement of respiratory function in children and adults at a slightly better evaluation of efficacy. – Non GMO Sustainably Sourced Vegetarian, Zarbee's Naturals Baby Cough Syrup with Agave & Thyme, Natural Cherry Flavor, 2 Ounce Bottle, Robitussin Naturals Cough Relief & Immune Health Syrup 8.3oz with Honey, Ivy Leaf & Zinc. In summary, the study showed that both preparations are effective and safe in the treatment of bronchitis. Coferb contains Ivy Leaf extract that relieves cough and congestion. Ivy leaf dry extract HRS European Pharmacopoeia (EP) Reference Standard; find null-Y0001592 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Criteria for exclusion of the documentation were as follows: known hypersensitivity to the active ingredients, treatment with the medications in the last two weeks before study entry, participation in another trial in the same time, and legal incapacity. [12] in children and adults. Furthermore bronchial muscle cells reduce under β2-stimulating conditions the intracellular Ca2+ level. Drop-outs were only those patients, for which no data after intake of the medication were available. Alternative & Herbal Products. Further, the patients were asked to keep a diary during the course of treatment, which includes following symptoms: number of coughing fits during daytime, coughing intensity, chest pain during coughing, dyspnoea during coughing, possibility to cough-up mucus, cough-related sleep disturbances, frequency of wake ups at night, and general well-being. In fact, a 2012 study involving 268 children, 0 to 12 years old, discovered that 14 days of treatment with ivy leaf extract (in the form of a cough syrup) was a safe and effective treatment for children with a cough. Nat Med 1999;14:28–33. If the standard deviations of the difference were on average not higher than 2 score points and the alpha error = 0.05, then [17] the nonparametric Mann–Whitney would demonstrate a statistical power (beta error) of more than 90% (GPower, Version 3.1.9, University of Düsseldorf, Germany). In the ACC group, 21 × 7.48 = 157 patient days were calculated together across all dosage forms. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Prime members enjoy FREE Delivery and exclusive access to music, movies, TV shows, original audio series, and Kindle books. The study was conducted at 25 medical practices throughout Switzerland as prospective, open, noninterventional study. English ivy leaf might cause skin irritation when taken by mouth. Comparable improvement was seen for all symptoms between both groups from the entry to final visit which was statistically significant. The level of significance was α = 0.05. Recommended dosage according to the Swiss patient leaflet: for children six years and older, 5 ml, three times daily, and for adults, 7.5 ml, three times daily. 47 male and 71 female subjects were included into the EA 575® group, and 11 male and 10 female subjects were included into the ACC group. The main components of ivy leaf that give it its health benefits are called saponins. The study revealed a significant and clinically relevant improvement in patients with acute bronchitis receiving oral treatment with EA 575®. Review articles are excluded from this waiver policy. And 10 children were between 14 and 17 years old with an average height of 166.1 cm and an average weight of 63.0 kg. In total, 139 data sets were analysed: 118 from the EA 575® group and 21 from the ACC group. It possesses antitussive and expectorant action that provides relief from bronchial cough and other associated respiratory afflictions. You may need to read it … Ivy Leaf Cough Syrup Benefits: Natural formula to reduce coughing, soothe airways and to clear mucus and phlegm or effective congestion and cough relief. dried ivy leaf extract 【Botanic Name】Hedera helix L. 【Use Part】Leaf 【Specifications】10%-40% Hederacosides, 3%-20% Hederacoside C, 10:1. Totally, 25 physicians were recruited in Switzerland who participated with 139 patients. Material and Methods. There was a significant improvement in the reduction of both groups from baseline to end visit. The exclusive ivy extract in Bronchial Soothe provides herbal support for optimal lung and bronchial passageway health. The research protocol was reviewed and approved by the Independent Ethics Committee, EKOS (Ethikkommission Ostschweiz) on 16.12.2016 (BASEC Nr. In Europe, the prevalence for cough is 33% in the population group aged 18 to 48 years [10]. Significant improvement in each of the symptoms from the entry visit to final visit (, Average values of physician`s evaluation for severity of disease and calculated BSS score at entry and final visit in both groups comparing the final visit with the entry visit. Diseases with the leading symptom “cough” are economically relevant as respiratory diseases are the most common reason for working incapacity and affect the quality of patient’s life [2]. One patient reported diarrhea after she had used EA 575® for two days, and after discontinuing of the medication, the patient had recovered. At the end of the treatment, the disease was reduced in both groups to a borderline case of 1.68 points in the EA 575® group and 1.86 points in the ACC group. Prospan Chesty Cough Relief - Prospan Australia - Prospan … Esther Kruttschnitt, Tankred Wegener, Catherine Zahner, Silke Henzen-Bücking, "Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis", Evidence-Based Complementary and Alternative Medicine, vol. Relevant concomitant diseases and treatments. 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